WebMay 1, 2024 · We developed a T-cell-receptor (TCR) complex-based chimeric antigen receptor (CAR) named S ynthetic T CR and A ntigen R eceptor (STAR). Here, we report pre-clinical and phase I clinical trial data (NCT03953599) of this T-cell therapy for refractory and relapsed (R/R) B-cell acute lymphoblastic leukemia (B-ALL) patients.
A novel adoptive synthetic TCR and antigen receptor (STAR) T …
WebJun 1, 2024 · Introduction. A new pillar in cancer immunotherapy has been the use of adoptively transferred T cells to help patients fight cancer. This approach includes tumor-infiltrating lymphocytes (TILs), T-cell receptor (TCR)-engineered T cells and chimeric antigen receptor (CAR) T cells. In 2024, the first CAR T cell therapy was approved by … WebNov 24, 2024 · Over the ensuing decade, the clinical development of CAR T cells targeting CD19 progressed rapidly, with FDA approvals based on single-arm phase 2 clinical trials in different types of B cell malignancies using four different CD19-directed CAR T cell products ().Tantalizingly, all these CD19-directed CAR T cell products result in durable remissions … sm30b-shls-tf lf sn
The Latest Research Progress of CAR-T Cell Therapy v1
WebJan 18, 2024 · Despite its success in treating hematologic malignancies, chimeric antigen receptor (CAR) T cell therapy faces two major challenges which hinder its broader applications: the limited effectiveness against solid tumors and the nonspecific toxicities. WebChimeric antigen receptor (CAR)–T cells can induce lasting responses in relapsed/refractory B cell malignancies. Hence, we investigated treatment of … WebMay 1, 2024 · Abstract. We developed a T-cell-receptor (TCR) complex-based chimeric antigen receptor (CAR) named S ynthetic T CR and A ntigen R eceptor (STAR). Here, … soldering iron machine mart