Webwith cisplatin in killing and inhibiting cancer cells in vitro; nevertheless, further in vivo study is required to confirm our findings. 14 This study was conducted to eval-uate the antitumor and anti-inflammatory effects of bro-melain and bromelain plus cisplatin on TNBC 4T1-challenged mice model. The result from this study WebNov 21, 2024 · Bromelain and cisplatin both positively reduced the tumor size and lung metastasis of 4T1-challenged mice. However, regulation of tumor inflammation by bromelain and cisplatin are different, whereas bromelain showed an anti-inflammation effect while cisplatin was observed with a pro-inflammation effect.
Cisplatin prevents breast cancer metastasis through blocking early EMT
WebAPE1 protein expression was examined by immunohistochemistry and Western blot on the tumor samples and a cultured A549 cell line, respectively. Cell survival and apoptosis were determined by MTT and TUNEL, respectively. WebObjective Cisplatin is a conventional anticancer drug that generates reactive oxygen species and causes apoptosis. However, many cancer cells develop alterations in the ATP binding cassette... norkys huandoy
Antimutagenic and Synergistic Cytotoxic Effect of
WebJul 4, 2024 · After IGFBP3 was overexpressed in HCC2429, and H460 which is relatively cisplatin resistant, a remarkable enhanced cisplatin response was found in both cell lines compared with single CDDP treatment, ... or severe lung metastasis of 4T1 cells injection . Researchers further investigated IGFBP3′s function under the oncogenic mutation … WebCisplatin is also used alone or in combination with other medications to treat bladder cancer that can not be treated with surgery or radiation therapy alone. Cisplatin is in a class of … WebFeb 26, 2024 · The main characteristics of pyroptosis include membrane perforation, cell swelling, the release of cellular content, chromatin condensation and DNA fragmentation (6, 7). In the canonical inflammasome pathway of pyroptosis, activated caspase-1 promotes the maturation of IL-1β and IL-18. norkys chorrillos