Web10 jul. 2024 · A Study to Evaluate the Effectiveness and Safety of IONIS-FB-LRx, ... ≤ 40 milliliters per minute per 1.73 square meters (mL/min/1.73m^2) using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) Presence of another renal disease including, but not limited to, diabetes and/or diabetic nephropathy, ... WebIONIS-DNM2-2.5Rx (DYM101) is an antisense agent targeting dynamin 2. IONIS-DNM2-2.5Rx has the potential for the research of centronuclear myopathy (CNM). For research …
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Web10 mei 2024 · IONIS-ENAC-2.5Rx is designed to reduce the expression of ENaC in the lung. ENaC is believed to be hyperactive in cystic fibrosis, which is caused by mutations … WebIONIS-AGT-L Rx is an investigational ligand-conjugated antisense (LICA) medicine designed to inhibit the production of angiotensinogen to decrease blood pressure in people with chronic heart failure with reduced ejection … church of england and henry viii
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Web9 nov. 2024 · CARLSBAD, Calif. and STRASBOURG, France, Nov. 9, 2024 /PRNewswire/ -- Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) and Dynacure announced today that Dynacure has licensed IONIS-DNM2-2.5 Rx (Dyn101), a Generation 2.5 antisense drug targeting dynamin 2 for the treatment of centronuclear myopathy (CNM), for which Ionis … WebIONIS-C9 Rx ION859 IONIS -DNM2 2.5 Rx ION283 ION373 ION716 16. 2024 Neurological Pipeline Performance Neurological Enrollment complete in the tominersen Phase 3 GENERATION HD1 study for Huntington’s disease, with data expected in 20241 First patient treated in Phase 2/3 DEVOTE study of higher dose SPINRAZA2 Web14 okt. 2024 · Ionis advances. Ionis is slightly further ahead, having reported some phase I data yesterday with IONIS-ENAC-2.5Rx. However, there is not much to go on: all the company has said is that in healthy volunteers given 75mg there was a mean 56% reduction in Enac mRNA expression – and that this was statistically significant, with p<0.05. church of england asset management