Irf5 protein half-life

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August undefined, 2024

WebApr 16, 2002 · Q13568 · IRF5_HUMAN Protein Interferon regulatory factor 5 Gene IRF5 Status UniProtKB reviewed (Swiss-Prot) Organism Homo sapiens (Human) Amino acids … WebJul 19, 2024 · IRF5 protein, human Ifnar1 protein, mouse Immunoglobulin G Interferon Regulatory Factors Irf5 protein, mouse Transcription Factors Receptor, Interferon alpha-beta lyn protein-tyrosine kinase src-Family Kinases

IRF5 interferon regulatory factor 5 [ Homo sapiens (human) ]

WebThe IRF5 protein from these reaction mixtures was further purified and analyzed by mass spectrometry, which revealed that peptides containing phosphorylated Ser-445 and Ser-434 of mIRF5 were greatly enriched in the reactions that contained IKKβ, whereas the total counts of mIRF5 peptides were similar in both reactions ( Fig. 3 B and C and Fig. S2 … WebMay 30, 2024 · Background. Community-acquired pneumonia (CAP) is a common disease with significant morbidity and mortality. Interferon regulatory factor 5 (IRF5), which induces type I interferons (IFNs) and cytokines such as interleukin (IL)-6, tumor necrosis factor (TNF)-α, IL-10, and interferon gamma-induced protein (IP)10, is a key transcription factor … fisher fast

RNAi Screen and Proteomics Reveal NXF1 as a Novel Regulator of IRF5 …

WebHere, we designed antagonistic cell-penetrating peptides (CPPs) by incorporating the native amino acid sequence of IRF5 to directly interrogate the mechanism (s) of IRF5 activation and function in human primary immune cells. RESULTS Identification of novel CPP motifs and design of CPPs targeting IRF5 WebMay 19, 2024 · IRF5 is activated by phosphorylation and ubiquitination events downstream of pattern recognition receptors (PRRs), e.g., nucleotide-binding oligomerization domain-containing protein 2 (NOD2), Toll-like receptor 2 (TLR2), and TLR4, and directly regulates many cytokines associated with IBD (IL-1β, IL-6, IL-10, IL-12, IL-23, and TNF), placing IRF5 … WebJan 20, 2014 · Interferon regulatory factor 5 (IRF5) modulates the expression of genes controlling cell growth and apoptosis. ... The increased IM sensitivity of K562 and KYO1 cells lentivirally transduced with IRF5 established that this protein could also reduce CML cell viability in response to BCR-ABL kinase inactivation. Previous evidence has shown that, ... canadian bedding online stores canada

Activation of Interferon Regulatory Factor 5 by Site Specific ... - PLOS

WebSep 10, 2024 · IRF5 is highly expressed in not only monocytes and macrophages but also in B cells and dendritic cells. Its expression in macrophages can be upregulated in response to the inflammatory … WebOct 5, 2008 · The physiological importance of IRF5 makes it an important prototype for investigating regulation of IRF proteins. IRF proteins, including IRF5, comprise two major domains, an N-terminal DNA... canadian beef improvement networkWebOct 29, 2024 · Interferon regulatory factor-5 (IRF5) is a member of the IRF transcription factor family and is important for inducing the innate immune responses mediated by Toll … canadian beef research council

"WebIRF5 resides in the cytoplasm of most unstimulated cells and becomes activated by posttranslational modifications that include phosphorylation, acetylation, and/or ubiquitination, resulting in translocation to the nucleus ( 2, 13, 18 – 22 ). " - Irf5 protein half-life

Irf5 protein half-life

WebOct 5, 2008 · A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus. … WebJun 2, 2024 · Stimulation with TLR7 ligand enhances formation of IRF5-NXF1 protein complexes. Gain or loss-of-function experiments revealed NXF1 selectively regulates TLR7-driven IRF5 transcriptional activity ...

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WebMar 21, 2024 · Title: Interferon regulatory factor 5‑induced upregulation of zinc‑finger protein 217 promotes pancreatic carcinoma progression. One gut microbiota, … WebMar 21, 2024 · IRF5 (Interferon Regulatory Factor 5) is a Protein Coding gene. Diseases associated with IRF5 include Systemic Lupus Erythematosus 10 and Inflammatory Bowel …

WebThe protein produced from the IRF5 gene, called interferon regulatory factor 5 (IRF5), acts as a transcription factor, which means that it attaches (binds) to specific regions of DNA and … WebMar 29, 2024 · The Interferon regulatory factors (IRFs) are a family of transcription factors that play pivotal roles in many aspects of the immune response, including immune cell development and differentiation and regulating responses to pathogens. Three family members, IRF3, IRF5, and IRF7, are critical to production of type I interferons downstream …

WebInterferon regulatory factor 5 (IRF5) belongs to a family of transcription factors, originally implicated in antiviral responses and interferon production. However, studies conducted … WebApr 17, 2007 · These alterations in IRF5 protein structure and expression levels presumably shape the IRF5 transcriptional cascade and downstream immune responses. It has been shown that IRF5 is activated by Toll-like receptors 7/9 and type 1 IFN signaling and that, upon stimulation, different IRF5 protein isoforms differentially activate transcription of ...

WebIRF5 is a transcription factor that functions as a central mediator of Toll-like receptor signaling and is involved in the production of type I IFN, apoptosis, cell-cycle regulation, …

WebIRF5 protein expression summary - The Human Protein Atlas. IRF5. PROTEIN SUMMARY SECTION OVERVIEW RNA DATA ANTIBODY DATA. IRF5 INFORMATION. Proteini. Full gene name according to HGNC. Interferon regulatory factor 5. Gene namei. Official gene … IRF5. SECTIONS. TISSUE BRAIN SINGLE CELL TYPE TISSUE CELL TYPE … This section contains Pathology information based on mRNA and protein … In total, 16465 of all human protein coding genes (n=20090) are detected in the … Protein tyrosine phosphatase non-receptor type 18: 0.7333: 64: COTL1: Coactosin … Expression of IRF5 in skin tissue. Antibody staining with HPA046700 and … Expression of IRF5 in breast tissue. Antibody staining with HPA046700 and … IRF5 protein expression summary. We use cookies to enhance the usability of our … Expression of IRF5 in testis tissue. Antibody staining with HPA046700 and … Expression of IRF5 in urinary bladder tissue. Antibody staining with HPA046700 and … Expression of IRF5 in appendix tissue. Antibody staining with HPA046700 and … canadian beef cattle check offWebJan 1, 2016 · IRF5 has been shown to be extremely important for increased and prolonged TNF production in inflammatory (M1) macrophages, compared with anti-inflammatory (M2) macrophages in vitro. 21, 22 ChIP seq studies of genome-wide IRF5 recruitment have extended this observation to many inflammatory genes that IRF5 regulates in cooperation … fisher fastenersWebOct 29, 2024 · The transcription factor interferon regulatory factor-5 (IRF5) plays an important role in innate immune responses via the TLR-MyD88 (Toll-like receptor - … fisherfast onlineWebIn the absence of TRAIL, little change in IRF5 protein levels were observed at 4 h post-CHX treatment (Fig. 4A, 6, and 7C); however, in the presence of TRAIL and CHX, IRF5 degradation was readily ... fisher fast canadaWebNov 20, 2024 · Figure 2.The Serine Rich Region (SRR) is conserved in all IRF5 isoforms. The C-terminus contains conserved serine (S) residues that are targeted for phosphorylation … fisher fasteners in massWebApr 17, 2007 · Estimates for the half-life of these transcripts, based on regression curves, were: 342 ± 88 min for the short allele and 125 ± 21 min for the long allele. By comparison, … canadian beer labels for saleWebInterferon regulatory factor 5 (IRF5) is a crucial transcription factor in a number of immune and homeostatic processes, including host defense against pathogens, tumorigenesis, and autoimmunity. fisherfast mercedes