SCF contains a variable F-box protein and three core subunits: • F-box protein (FBP) – FBP contributes to the substrate specificity of the SCF complex by first aggregating to target proteins independently of the complex. Each FBP (e.g. Skp2) may recognize several different substrates in a manner that is dependent on post-translational modifications such as phosphorylation or glycosylation. FBP then binds to Skp1 of the SCF complex using an … http://www.plant-physiology.com/upload/file/201304271458507509.pdf
S单元型特异F-box蛋白基因(SFB),S haplotype-specific F-box …
WebF-Box 结构域介导与 SKP1 的相互作用,SKP1 将 F-Box 蛋白连接到核心泛素-连接酶复合体,该复合体由 Rbx1、cdc53/Cul1 和 E2 偶联酶 cdc34 组成。 F-Box 蛋白的羧基末端区域 … WebJul 12, 2024 · 泛素-蛋白酶体系统(ubiquitin-proteasome system, UPS)是细胞内调控蛋白质降解和维持细胞蛋白质稳态的主要途径,其中,SKP1-CUL1-F-box(SCF)泛素E3连接酶 ... broadway theater vista ca
泛素化:通路调控、病理过程、药物研发和实验手段 – 王进的个人 …
Web4.12.3.2.2.1 The SKP1-Cullin-F-Box Protein Complex. The SKP1-cullin-F-Box protein (SCF) complex contains at least four proteins: Skp1, Cul1, Roc1/Rbx1/Hrt1, and an F-box protein (Fig. 2). In the center of the SCF complex is the RING finger domain–containing protein Rbx1. The SCF type ligases have another invariant protein called cullin. WebJul 13, 2024 · 泛素-蛋白酶体系统(ubiquitin-proteasome system, UPS)是细胞内调控蛋白质降解和维持细胞蛋白质稳态的主要途径,其中 SKP1-CUL1-F-box (SCF)泛素E3连接酶复合物属于最大的Cullin-RING泛素E3连接酶家族成员,其介导细胞周期运转、DNA损伤修复、肿瘤发生发展等许多关键生理病理过程。 WebJul 13, 2024 · 泛素化降解蛋白质需要通过泛素化蛋白酶体来实现,蛋白酶体存在于细胞质和细胞核,是一种由十到二十个亚基组成的蛋白复合物。 ... 在以SKP2为靶点的抑制剂中,Cpd A可通过阻止SKP2进入SCF(Skp1-Cul1-F-box) ... carbohydrates suffixes